SCAD Information

What is SCAD

SCAD stands for short chain acyl-coa dehydrogenase deficiency, it is a Fatty Oxidation Disorder.

What causes SCAD

A person is affected with this disorder when they are missing or lacking full function of a certain enzyme, this enzyme is called short chain acyl coa. This enzymes job is to break down fats in our food and the body then converts this into energy.

The Types of SCAD and symptoms: There are 3 types

  • Early SCAD – showing signs from birth to a few months old.
  • Childhood SCAD- Showing signs from late infancy into early childhood.
  • Adult SCAD- Showing signs into teenage years through to adulthood.

SCAD deficiency may appear in the above stages and can include vomiting, low blood sugar (hypoglycaemia), a lack of energy (lethargy), failure to gain weight and grow at the expected rate (failure to thrive). other features of this disorder may include poor muscle tone (hypotonia), seizures, developmental delay and a small head size (microcephaly)

The symptoms of SCAD deficiency may be triggered by fasting or illness such as a viral infection. This disorder is sometimes mistaken for Reye Syndrome, a severe condition that may develop in children while they appear to be recovering from viral infections such as Chicken Pox or Flu. Most cases of Reye Syndrome are associated with the use of Aspirin during these viral infections.

In some people with SCAD Deficiency, signs and symptoms do not appear until adulthood and some of these individuals are more likely to have problems related to muscle weakness and wasting.